Charlotte moves to Clamburg from Vermont. Vendetta, a mysterious evil girl, terrorizes the city. Charlotte is unaware of evilness, and thinks Vendetta is her best friend.

For Show and Tell, Vendetta releases a monkey fiend, that eats Marion's unicorn toy and throws away Marvin's bananas, but things go awry when Charlotte introduces Buttons, her hamster, to the Giant Kitty.

Charlotte notices that there are no vegetables in the school menu, after Vendetta hears about that, she decides to make some screamy vegetables fiends.

After Charlotte bothers Vendetta too much, so she decides to make her a snipping fiend, but the plan backfires when Charlotte befriends the fiend with love and renames him Buttons 2.

It's Halloween and Charlotte dresses up as Vendetta and Vendetta gets the plan to get rid of her by making a fiend that only eats and drinks blood if he eats Charlotte.

Vendetta makes a slug that shrinks whoever touches it, but when Vendetta and Grudge accidentally get small they make growing squid.

Charlotte keeps bugging Vendetta about her birthday. So, Vendetta makes a birthday party with many hazardous things like balloons that tie you very tight, a man-eating birthday hat, a taunting present wanting her liver, and an exploding strawberry birthday cake.

When Mr. Milk is sick, Mrs. Minty, the substitute teacher, is trying to teach the class.

Charlotte shows Vendetta her canary and Vendetta lies by saying she is going to Florida so Charlotte can care for her fiends.

Charlotte was eaten by the Giant Kitty fiend much to the delight of Vendetta. But Vendetta is eaten as well and ended up, trapped, in the Giant Kitty's stomach with Charlotte. Vendetta soon sets a boundary for them because of Charlotte's annoyance.

To celebrate Chester A. Arthur's birthday, Vendetta calls for an election for class president. Charlotte nominates Marion, against her own will, while Vendetta nominates Marvin to try to beat Charlotte.

Vendetta brings an invisible fiend to attack Charlotte, however, Charlotte accidentally turns invisible herself by drinking Vendetta's potion.

When Vendetta decides to skip a school day, Mr. Milk is very happy because he actually doesn't have to do what Vendetta wants him to do for a change. Soon he starts to sing a song and gets the rest of the class to sing with him.

During Valentine's Day, Charlotte sends a Valentine's Day card to Vendetta and, out of irritation, she creates a big heart fiend who wants everyone's hearts.

Vendetta calls for a "Rainy Day schedule" because of the precipitation outside. She brings out a Rainy Day Activity Box because Charlotte annoys her and pleads for it unknowing of what would happen. Vendetta opens the box and out come these noise-making fiends which make very loud, screeching noises.

During April Fools' Day, Vendetta plots to send Charlotte into space because of Charlotte's annoying April Fools'. Vendetta, however, gets tied onto the rocket that was going to be launched into space because of her colorblind fiends. Charlotte wants to join her and they both get launched into space.

Charlotte gives Vendetta a music card which is very irritating to Vendetta. To stop the noise, Grudge eats it, but when he hiccups the song plays which still annoys Vendetta. She fires him and makes a new fiend to her sidekick, Rubella who helps her destroy Charlotte.

After having been tricked into the ocean while wearing concrete shoes, Charlotte is trapped at the bottom of the ocean. She manages to survive when Buttons 2 drops a salad bowl onto her head.

Charlotte returned in this episode by a friendly squid named Janet. Vendetta, waiting to destroy Charlotte this time, creates a potion that will turn anything into a fiend. Charlotte finds the paint and uses it to paint a statue of Vendetta. The statue soon comes to life along with all other buildings in Clamburg, making the town an unsafe place to live.