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Dale Denton (Rogen) is a 25 year-old process server about to serve a drug lord named Ted Jones (Gary Cole). He witnesses Jones and a corrupt female police officer, Carol Brazier (Rosie Perez), commit murder. Dale panics and leaves a roach at the scene containing a rare strain of cannabis called Pineapple Express. Ted picks up the roach and identifies it as the rare strain that he has only sold to one dealer. He sends his henchmen, Matheson (Craig Robinson) and Budlofsky (Kevin Corrigan), to this dealer, Red (Danny R. McBride) who discloses that he has only sold this cannabis to Dale's dealer, Saul Silver (Franco).

Dale tells Saul what he saw because he anticipates that the roach will lead Ted to Saul. They flee Saul's apartment. Ted's henchmen persuade Saul's supplier, Red, to arrange a meeting between Red and Saul, but this fails because Dale and Saul spend the night in the woods. Matheson and Budlofsky learn Dale's identity through Red.

Dale and Saul sleep 18 hours after getting stoned, so they visit Red after the agreed upon time. They hope that talking with Red in person will help them determine that Ted has not linked them, and is not in pursuit of them. Instead, Dale determines that Red intends to reveal their whereabouts to Ted, and the three fight. Convinced that Ted's men are pursuing them, they decide that they must leave the city. Dale goes to his girlfriend Angie's (Amber Heard) house to warn her and her parents, but Angie's dad doesn't believe him. Instead, he threatens to shoot Dale. Matheson and Budlofsky pursue Dale and Saul to Angie's house, and her family goes into hiding.

To leave town Dale and Saul sell some of Saul's Pineapple Express to raise bus fare. Dale is identified as the driver of the car that recently battered a police squad car - that Officer Carol parked at Ted's while she helped murder the victim, so Dale is arrested. Handcuffed in the back of a squad car, Dale manages to convince the arresting officer that Officer Brazier is corrupt. Saul 'saves' Dale by gaining control of the squad car, and drives away with Dale handcuffed in the back seat. Officer Braizer hears a police radio call of Dale's arrest for battering a police car, and pursues Dale and Saul in a high speed chase, but Dale and Saul evade her.

Dale and Saul fight and split up. Saul visits his grandmother in an assisted living home and finds Budlofsky and Matheson looking for him. They kidnap Saul and take him to Ted's lair, a barn and underground pot factory which used to be an old Army base. Dale enlists Red to help him rescue Saul from Ted, but Red backs out at the last minute and Dale is captured.

While Dale and Saul are captive, a rival Asian drug gang attacks the barn in revenge for Ted and Carol killing the fellow gang member that Dale witnessed. Dale and Saul free themselves, and Dale fights with Ted and Saul fights with Carol. Red returns and saves Saul. A rival gang member sets off a bomb that destroys the barn, and kills Ted and Carol. Dale carries an unconscious Saul out of the burning barn, and Red crawls from the wreckage.

Saul, Dale and Red go to a diner for breakfast, reminisce about the events and bond, before Saul's grandmother takes them home.